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Winston Peki

61 Potential Benefits of Marijuana and Its Cannabinoids that Are Backed By Scientific Research

Today you're going to learn the potential benefits of marijuana. We analyzed over 150 scientific papers to find all potential benefits of marijuana. Some of these studies are human studies, while others are animal studies. Keep in mind that the results of animal studies can't be directly ... Continue Reading

Finding The Most Efficient Vaporizer & 5 Simple Tricks to Save Your Hard Earned Money

Most Efficient Vaporizer

In a day and age where efficiency is an obsession in literally everything we do… Getting a vaporizer that's the most efficient with your herb is a quest worth pursuing. While vaporizing in and of itself is already way more efficient than smoking: You will inhale 50% to 80% more cannabinoids ... Continue Reading

Best Temperature to Vape Weed: the Advanced Guide

Best Temperature to Vape Weed

It's one of the most unclear and controversial topics in dry herb vaping: Choosing the best temperature to vape weed. It turns out, there is no single best temperature to vape weed. The best temperature to vape weed is dependent on what effects you're looking for. But it oscillates between ... Continue Reading

The CRAFTY+ Vaporizer Reviewed and Compared to its Competition

crafty_vaporizer_in_hand

Today you're getting the results of our month-long review of the CRAFTY+. We tested the CRAFTY+ on every possible metric a vaporizer can be tested on: Vapor quality; Battery-life; Draw-resistance; Efficiency, and many other metrics that you'll learn about today. We also compared ... Continue Reading

VapeXhale Cloud EVO Reviewed and Compared to its Competition

VapeXhale Cloud EVO Reviewed and Compared to its Competition

Today you're getting the results of our month-long review of the VapeXhale Cloud EVO. We tested the VapeXhale Cloud EVO on every possible metric a vaporizer can be tested on: Vapor quality; Battery-life; Draw-resistance; Efficiency, and many other metrics which you'll learn about ... Continue Reading

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© Copyright www.herbonaut.com · All Rights Reserved. The content on this website is for informational purposes only and is not intended as medical advice. Medical advice should always be obtained from a qualified medical professional for any health conditions or symptoms associated with them. Every possible effort has been made in preparing and researching this material. We make no warranties with respect to the accuracy, applicability of its contents or any omissions.

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When we recommend products we link out to them. Most of the time this will be through an affiliate link. If you decide to buy a product through our affiliate links, we may earn a commission at no extra cost to you. By using these links, we can continue to grow this website by testing new products and writing new articles/reviews, and keep the website ad-free.

In no way do these affiliate links influence the products that we recommend. This website is first and foremost built on trust and honesty. We are 100% convinced that you’ll come to the same conclusion by following up on our advice. In case you feel our advice was not what you expected, please do contact us, as we would love to hear from you and have a friendly discussion with you about your experiences and findings!

Scientific References

Musty, R. E., & Rossi, R. (2001). Effects of Smoked Cannabis and Oral δ9-Tetrahydrocannabinol on Nausea and Emesis After Cancer Chemotherapy. Journal of Cannabis Therapeutics, 1(1), 29–56. https://doi.org/10.1300/j175v01n01_03

Mattes, R. D., Engelman, K., Shaw, L. M., & Elsohly, M. A. (1994). Cannabinoids and appetite stimulation. Pharmacology Biochemistry and Behavior, 49(1), 187–195. https://doi.org/10.1016/0091-3057(94)90475-8

Foltin, R. W., Fischman, M. W., & Byrne, M. F. (1988). Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Appetite, 11(1), 1–14. https://doi.org/10.1016/s0195-6663(88)80017-5

Corey-Bloom, J., Wolfson, T., Gamst, A., Jin, S., Marcotte, T. D., Bentley, H., & Gouaux, B. (2012). Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. Canadian Medical Association Journal, 184(10), 1143–1150. https://doi.org/10.1503/cmaj.110837

Kim, K., Moore, D. H., Makriyannis, A., & Abood, M. E. (2006). AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. European journal of pharmacology, 542(1-3), 100–105. https://doi.org/10.1016/j.ejphar.2006.05.025

Institute of Medicine (US); Joy JE, Watson SJ Jr., Benson JA Jr., editors. Marijuana and Medicine: Assessing the Science Base. Washington (DC): National Academies Press (US); 1999. 4, The Medical Value of Marijuana and Related Substances. Available from: https://www.ncbi.nlm.nih.gov/books/NBK230711/

Rosenberg, E. C., Tsien, R. W., Whalley, B. J., & Devinsky, O. (2015). Cannabinoids and Epilepsy. Neurotherapeutics, 12(4), 747–768. https://doi.org/10.1007/s13311-015-0375-5

Ware, M. A., Wang, T., Shapiro, S., Robinson, A., Ducruet, T., Huynh, T., Gamsa, A., Bennett, G. J., & Collet, J. P. (2010). Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 182(14), E694–E701. https://doi.org/10.1503/cmaj.091414

Wang, Z. Y., Wang, P., & Bjorling, D. E. (2014). Treatment with a Cannabinoid Receptor 2 Agonist Decreases Severity of Established Cystitis. Journal of Urology, 191(4), 1153–1158. https://doi.org/10.1016/j.juro.2013.10.102

Greco, R., Gasperi, V., Maccarrone, M., & Tassorelli, C. (2010). The endocannabinoid system and migraine. Experimental Neurology, 224(1), 85–91. https://doi.org/10.1016/j.expneurol.2010.03.029

Richardson, D., Pearson, R. G., Kurian, N., Latif, M. L., Garle, M. J., Barrett, D. A., Kendall, D. A., Scammell, B. E., Reeve, A. J., & Chapman, V. (2008). Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis research & therapy, 10(2), R43. https://doi.org/10.1186/ar2401

Kong, Y., Wang, W., Zhang, C., Wu, Y., Liu, Y., & Zhou, X. (2016). Cannabinoid WIN‑55,212‑2 mesylate inhibits ADAMTS‑4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan‑1. Molecular medicine reports, 13(6), 4569–4576. https://doi.org/10.3892/mmr.2016.5137

D. R. Blake, P. Robson, M. Ho, R. W. Jubb, C. S. McCabe, Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis, Rheumatology, Volume 45, Issue 1, January 2006, Pages 50–52, https://doi.org/10.1093/rheumatology/kei183

Fiz, J., Durán, M., Capellà, D., Carbonell, J., & Farré, M. (2011). Cannabis Use in Patients with Fibromyalgia: Effect on Symptoms Relief and Health-Related Quality of Life. PLoS ONE, 6(4), e18440. https://doi.org/10.1371/journal.pone.0018440

Bab, I., Zimmer, A., & Melamed, E. (2009). Cannabinoids and the skeleton: From marijuana to reversal of bone loss. Annals of Medicine, 41(8), 560–567. https://doi.org/10.1080/07853890903121025

Silveira, J. W., Issy, A. C., Castania, V. A., Salmon, C. E., Nogueira-Barbosa, M. H., Guimarães, F. S., Defino, H. L., & Del Bel, E. (2014). Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. PloS one, 9(12), e113161. https://doi.org/10.1371/journal.pone.0113161

Consroe, P., Sandyk, R., & Snider, S. R. (1986). Open label evaluation of cannabidiol in dystonic movement disorders. International Journal of Neuroscience, 30(4), 277–282. https://doi.org/10.3109/00207458608985678

Blázquez, C., Chiarlone, A., Sagredo, O., Aguado, T., Pazos, M. R., Resel, E., . . . Guzmán, M. (2010). Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease. Brain, 134(1), 119–136. https://doi.org/10.1093/brain/awq278

Sieradzan, K., Fox, S., Hill, M., Dick, J., Crossman, A., & Brotchie, J. (2001). Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: A pilot study. Neurology, 57(11), 2108–2111. https://doi.org/10.1212/wnl.57.11.2108

Kirsten R. Müller-Vahl, "Treatment of Tourette Syndrome with Cannabinoids", Behavioural Neurology, vol. 27, Article ID 294264, 6 pages, 2013. https://doi.org/10.3233/BEN-120276

Tomida, I. (2004). Cannabinoids and glaucoma. British Journal of Ophthalmology, 88(5), 708–713. https://doi.org/10.1136/bjo.2003.032250

Williams, S. J., Hartley, J. P., & Graham, J. D. (1976). Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients. Thorax, 31(6), 720–723. https://doi.org/10.1136/thx.31.6.720

Crawford, W. J., & Merritt, J. C. (1979). Effects of tetrahydrocannabinol on arterial and intraocular hypertension. International journal of clinical pharmacology and biopharmacy, 17(5), 191–196. https://pubmed.ncbi.nlm.nih.gov/468444/

Bergamaschi, M. M., Queiroz, R. H. C., Chagas, M. H. N., de Oliveira, D. C. G., de Martinis, B. S., Kapczinski, F., . . . Crippa, J. A. S. (2011). Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients. Neuropsychopharmacology, 36(6), 1219–1226. https://doi.org/10.1038/npp.2011.6

Bambico, F. R., Katz, N., Debonnel, G., & Gobbi, G. (2007). Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex. Journal of Neuroscience, 27(43), 11700–11711. https://doi.org/10.1523/jneurosci.1636-07.2007

Russo, E., Guy, G., & Robson, P. (2007). Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials ofSativex®, a Cannabis-Based Medicine. Chemistry & Biodiversity, 4(8), 1729–1743. https://doi.org/10.1002/cbdv.200790150

Fraser, G. A. (2009). The Use of a Synthetic Cannabinoid in the Management of Treatment-Resistant Nightmares in Posttraumatic Stress Disorder (PTSD). CNS Neuroscience & Therapeutics, 15(1), 84–88. https://doi.org/10.1111/j.1755-5949.2008.00071.x

Reiman, A. Cannabis as a substitute for alcohol and other drugs. Harm Reduct J 6, 35 (2009). https://doi.org/10.1186/1477-7517-6-35

Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., . . . Koethe, D. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry, 2(3), e94. https://doi.org/10.1038/tp.2012.15

Eubanks, L. M., Rogers, C. J., Beuscher, Koob, G. F., Olson, A. J., Dickerson, T. J., & Janda, K. D. (2006). A Molecular Link between the Active Component of Marijuana and Alzheimer’s Disease Pathology. Molecular Pharmaceutics, 3(6), 773–777. https://doi.org/10.1021/mp060066m

Dvorak, M., Watkinson, A., McGlone, F., & Rukwied, R. (2003). Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin. Inflammation Research, 52(6), 238–245. https://doi.org/10.1007/s00011-003-1162-z

Wong, B. S., Camilleri, M., Busciglio, I., Carlson, P., Szarka, L. A., Burton, D., & Zinsmeister, A. R. (2011). Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients With Nonconstipated Irritable Bowel Syndrome. Gastroenterology, 141(5), 1638–1647.e7. https://doi.org/10.1053/j.gastro.2011.07.036

Naftali, T., Lev, L. B., Yablecovitch, D., Half, E., & Konikoff, F. M. (2011). Treatment of Crohn's disease with cannabis: an observational study. The Israel Medical Association journal : IMAJ, 13(8), 455–458. https://pubmed.ncbi.nlm.nih.gov/21910367/

Lim, M. P., Devi, L. A., & Rozenfeld, R. (2011). Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. Cell Death & Disease, 2(6), e170. https://doi.org/10.1038/cddis.2011.52

Levendal, R. A., Schumann, D., Donath, M., & Frost, C. (2012). Cannabis exposure associated with weight reduction and β-cell protection in an obese rat model. Phytomedicine, 19(7), 575–582. https://doi.org/10.1016/j.phymed.2012.02.001

Rajavashisth, T. B., Shaheen, M., Norris, K. C., Pan, D., Sinha, S. K., Ortega, J., & Friedman, T. C. (2012). Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. BMJ Open, 2(1), e000494. https://doi.org/10.1136/bmjopen-2011-000494

Scott, K. A., Dalgleish, A. G., & Liu, W. M. (2014). The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Molecular Cancer Therapeutics, 13(12), 2955–2967. https://doi.org/10.1158/1535-7163.mct-14-0402

Elbaz, M., Nasser, M. W., Ravi, J., Wani, N. A., Ahirwar, D. K., Zhao, H., Oghumu, S., Satoskar, A. R., Shilo, K., Carson, W. E., 3rd, & Ganju, R. K. (2015). Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer. Molecular oncology, 9(4), 906–919. https://doi.org/10.1016/j.molonc.2014.12.010

Adinolfi, B., Romanini, A., Vanni, A., Martinotti, E., Chicca, A., Fogli, S., & Nieri, P. (2013). Anticancer activity of anandamide in human cutaneous melanoma cells. European Journal of Pharmacology, 718(1–3), 154–159. https://doi.org/10.1016/j.ejphar.2013.08.039

Thomas, A. A., Wallner, L. P., Quinn, V. P., Slezak, J., van den Eeden, S. K., Chien, G. W., & Jacobsen, S. J. (2015). Association Between Cannabis Use and the Risk of Bladder Cancer: Results From the California Men’s Health Study. Urology, 85(2), 388–393. https://doi.org/10.1016/j.urology.2014.08.060

Scott, K. A., Shah, S., Dalgleish, A. G., & Liu, W. M. (2013). Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules. Anticancer research, 33(10), 4373–4380. https://pubmed.ncbi.nlm.nih.gov/24123005/

Haustein, M., Ramer, R., Linnebacher, M., Manda, K., & Hinz, B. (2014). Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochemical Pharmacology, 92(2), 312–325. https://doi.org/10.1016/j.bcp.2014.07.014

Carracedo, A., Gironella, M., Lorente, M., Garcia, S., Guzmán, M., Velasco, G., & Iovanna, J. L. (2006). Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes. Cancer Research, 66(13), 6748–6755. https://doi.org/10.1158/0008-5472.can-06-0169

Aviello, G., Romano, B., Borrelli, F., Capasso, R., Gallo, L., Piscitelli, F., . . . Izzo, A. A. (2012). Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. Journal of Molecular Medicine, 90(8), 925–934. https://doi.org/10.1007/s00109-011-0856-x

Olea-Herrero, N., Vara, D., Malagarie-Cazenave, S., & Díaz-Laviada, I. (2009). Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB2. British Journal of Cancer, 101(6), 940–950. https://doi.org/10.1038/sj.bjc.6605248

Deiana, S., Watanabe, A., Yamasaki, Y., Amada, N., Arthur, M., Fleming, S., . . . Riedel, G. (2011). Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour. Psychopharmacology, 219(3), 859–873. https://doi.org/10.1007/s00213-011-2415-0

Steffens, S., Veillard, N. R., Arnaud, C., Pelli, G., Burger, F., Staub, C., Karsak, M., Zimmer, A., Frossard, J. L., & Mach, F. (2005). Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature, 434(7034), 782–786. https://doi.org/10.1038/nature03389

Campos, A. C., Ortega, Z., Palazuelos, J., Fogaça, M. V., Aguiar, D. C., Díaz-Alonso, J., . . . Guimarães, F. S. (2013). The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system. International Journal of Neuropsychopharmacology, 16(6), 1407–1419. https://doi.org/10.1017/s1461145712001502

Nguyen, B. M., Kim, D., Bricker, S., Bongard, F., Neville, A., Putnam, B., . . . Plurad, D. (2014). Effect of Marijuana Use on Outcomes in Traumatic Brain Injury. The American Surgeon, 80(10), 979–983. https://doi.org/10.1177/000313481408001015

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Abush, H., & Akirav, I. (2013). Cannabinoids Ameliorate Impairments Induced by Chronic Stress to Synaptic Plasticity and Short-Term Memory. Neuropsychopharmacology, 38(8), 1521–1534. https://doi.org/10.1038/npp.2013.51

Liao, Y., Bin, J., Luo, T., Zhao, H., Ledent, C., Asakura, M., . . . Kitakaze, M. (2013). CB1 cannabinoid receptor deficiency promotes cardiac remodeling induced by pressure overload in mice. International Journal of Cardiology, 167(5), 1936–1944. https://doi.org/10.1016/j.ijcard.2012.05.033

Campos, A., Brant, F., Miranda, A., Machado, F., & Teixeira, A. (2015). Cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. Neuroscience, 289, 166–180. https://doi.org/10.1016/j.neuroscience.2014.12.051

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Science Based

This article is based on scientific studies, written by Winston Peki and fact-checked by experts.

Inside this article, you can find references to peer-reviewed scientific studies. The numbers in the parentheses (1, 2, …) are clickable links to these peer-reviewed scientific studies. In some cases, the link will give you direct access to the study, while in other cases if you want to read the full study, you either have to pay the publisher a fee or find a free version of the study elsewhere.

Herbonaut is a review and discussion platform that highly values honesty, integrity, and objectivity. We always strive to highlight the benefits, as well as the risks of a specific product or service.

Any topic can be approached from various angles, at Herbonaut we strive to highlight all these angles and will often examine and compare research with contradicting results.