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Winston Peki

How to Use CBD for Arthritis: What Science Can Tell us About Effects and Dosages

Today we are going to learn about how CBD can be used to help with arthritis symptoms. We reviewed clinical and preclinical studies that looked at: The potential anti-inflammatory and analgesic properties of CBD What mechanisms of action give CBD its anti-arthritic properties How ... Continue Reading

5 Biggest Myths About CBD Oil Exposed

There are many myths about CBD. And while most of them are innocent… Some myths are outright dangerous. For example: If you’re regularly drug-tested, you can easily fail a drug test by taking full-spectrum CBD products. But there are more myths. We’ll start with the ... Continue Reading

How to Dose CBD Products?

If you’ve been struggling to find clear information on how to dose CBD products, the tips in this guide will help you find the perfect dose. We analyzed over 40 scientific articles to look for CBD dosage guidelines. Plus, we reviewed over 50 CBD oils to see what doses and methods worked best for ... Continue Reading

Does CBD Oil Expire? How to Avoid Health Risks With Expired CBD

Maybe you have CBD oil in your closet that you bought 2 years ago. Maybe your CBD oil passed its expiration date. But can CBD oil even expire? Short answer: Yes, CBD oil can expire. But that doesn't necessarily mean that your CBD oil is 'bad' after its expiration date. Today you're ... Continue Reading

The Best Dry Herb Vaporizers Under $100 In 2023

Most beginners think that dry herb vaping is expensive.But here's the truth: A dry herb vaporizer doesn't have to cost more than $100. You can even get started with just $60. Today you're getting the best affordable dry herb vaporizers with a price tag of around $100 or lower. We rated ... Continue Reading

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© Copyright www.herbonaut.com · All Rights Reserved. The content on this website is for informational purposes only and is not intended as medical advice. Medical advice should always be obtained from a qualified medical professional for any health conditions or symptoms associated with them. Every possible effort has been made in preparing and researching this material. We make no warranties with respect to the accuracy, applicability of its contents or any omissions.

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When we recommend products we link out to them. Most of the time this will be through an affiliate link. If you decide to buy a product through our affiliate links, we may earn a commission at no extra cost to you. By using these links, we can continue to grow this website by testing new products and writing new articles/reviews, and keep the website ad-free.

In no way do these affiliate links influence the products that we recommend. This website is first and foremost built on trust and honesty. We are 100% convinced that you’ll come to the same conclusion by following up on our advice. In case you feel our advice was not what you expected, please do contact us, as we would love to hear from you and have a friendly discussion with you about your experiences and findings!

Scientific References

Arout, C. A., Haney, M., Herrmann, E. S., Bedi, G., & Cooper, Z. D. (2021). A placebo‐controlled investigation of the analgesic effects, abuse liability, safety and tolerability of a range of oral cannabidiol doses in healthy humans. British Journal of Clinical Pharmacology, 88(1), 347–355. https://doi.org/10.1111/bcp.14973

Baswan, S. M., Klosner, A. E., Glynn, K., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic potential of cannabidiol (CBD) for skin health and disorders. Clinical, Cosmetic and Investigational Dermatology, Volume 13, 927–942. https://doi.org/10.2147/ccid.s286411

Burstein, S. (2015). Cannabidiol (CBD) and its analogs: A review of their effects on inflammation. Bioorganic & Medicinal Chemistry, 23(7), 1377–1385. https://doi.org/10.1016/j.bmc.2015.01.059

Carrier, E. J., Auchampach, J. A., & Hillard, C. J. (2006). Inhibition of an equilibrative nucleoside transporter by Cannabidiol: A mechanism of cannabinoid immunosuppression. Proceedings of the National Academy of Sciences, 103(20), 7895–7900. https://doi.org/10.1073/pnas.0511232103

Cuñetti, L., Manzo, L., Peyraube, R., Arnaiz, J., Curi, L., & Orihuela, S. (2018). Chronic pain treatment with cannabidiol in kidney transplant patients in Uruguay. Transplantation Proceedings, 50(2), 461–464. https://doi.org/10.1016/j.transproceed.2017.12.042

Darkovska-Serafimovska, M., Serafimovska, T., Arsova-Sarafinovska, Z., Stefanoski, S., Keskovski, Z., & Balkanov, T. (2018). Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases. Journal of Pain Research, Volume 11, 837–842. https://doi.org/10.2147/jpr.s160556

De Petrocellis, L., Ligresti, A., Moriello, A. S., Allarà, M., Bisogno, T., Petrosino, S., Stott, C. G., & Di Marzo, V. (2011). Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. British Journal of Pharmacology, 163(7), 1479–1494. https://doi.org/10.1111/j.1476-5381.2010.01166.x

Fitzcharles, M. A., Clauw, D. J., & Hauser, W. (2020). A cautious hope for Cannabidiol (CBD) in rheumatology care. Arthritis Care & Research. https://doi.org/10.1002/acr.24176

Hammell, D. C., Zhang, L. P., Ma, F., Abshire, S. M., McIlwrath, S. L., Stinchcomb, A. L., & Westlund, K. N. (2015). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European Journal of Pain, 20(6), 936–948. https://doi.org/10.1002/ejp.818

Kotschenreuther, K., Waqué, I., Yan, S., Meyer, A., Haak, T., von Tresckow, J., Schiller, J., Gloyer, L., Dittrich-Salamon, M., & Kofler, D. M. (2020). Cannabinoids drive th17 cell differentiation in patients with rheumatic autoimmune diseases. Cellular & Molecular Immunology, 18(3), 764–766. https://doi.org/10.1038/s41423-020-0437-4

Lindstedt, F., Karshikoff, B., Schalling, M., Olgart Höglund, C., Ingvar, M., Lekander, M., & Kosek, E. (2012). Serotonin-1A receptor polymorphism (RS6295) associated with thermal pain perception. PLoS ONE, 7(8). https://doi.org/10.1371/journal.pone.0043221

Lowin, T., Tingting, R., Zurmahr, J., Classen, T., Schneider, M., & Pongratz, G. (2020). Cannabidiol (CBD): A killer for inflammatory rheumatoid arthritis synovial fibroblasts. Cell Death & Disease, 11(8). https://doi.org/10.1038/s41419-020-02892-1

Khaleghi, M. (2020). New arthritis foundation guidelines on CBD use could be first of many more to come. Alternative therapies in health and medicine. Retrieved May 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/32035005/

Malfait, A. M., Gallily, R., Sumariwalla, P. F., Malik, A. S., Andreakos, E., Mechoulam, R., & Feldmann, M. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proceedings of the National Academy of Sciences, 97(17), 9561–9566. https://doi.org/10.1073/pnas.160105897

McPartland, J. M., & Russo, E. B. (2001). Cannabis and cannabis extracts. Journal of Cannabis Therapeutics, 1(3-4), 103–132. https://doi.org/10.1300/j175v01n03_08

Miller , R. J., & Miller, R. E. (2017). Is cannabis an effective treatment for joint pain? Clinical and experimental rheumatology. Retrieved May 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/28967368/

Pathak, N., Radford, Z. J., Kahan, J. B., Grauer, J. N., & Rubin, L. E. (2022). Publication frequency and google trends analysis of popular alternative treatments to arthritis. Arthroplasty Today, 14, 76–80. https://doi.org/10.1016/j.artd.2021.12.009

Philpott, H. T., O'Brien, M., & McDougall, J. J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12), 2442–2451. https://doi.org/10.1097/j.pain.0000000000001052

Russo, E. B., Burnett, A., Hall, B., & Parker, K. K. (2005). Agonistic properties of cannabidiol at 5-HT1A receptors. Neurochemical Research, 30(8), 1037–1043. https://doi.org/10.1007/s11064-005-6978-1

Silmore, L. H., Willmer, A. R., Capparelli, E. V., & Rosania, G. R. (2021). Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of Clinical Studies. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 41(4), 405–420. https://doi.org/10.1002/phar.2512

Vela, J., Dreyer, L., Petersen, K. K., Arendt-Nielsen, L., Duch, K. S., & Kristensen, S. (2021). Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: A randomized, double-blind, placebo-controlled trial. Pain, Publish Ahead of Print. https://doi.org/10.1097/j.pain.0000000000002466

Watkins, A. R. (2019). Cannabinoid interactions with ion channels and receptors. Channels, 13(1), 162–167. https://doi.org/10.1080/19336950.2019.1615824

Xiong, W., Cui, T., Cheng, K., Yang, F., Chen, S.-R., Willenbring, D., Guan, Y., Pan, H.-L., Ren, K., Xu, Y., & Zhang, L. (2012). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209(6), 1121–1134. https://doi.org/10.1084/jem.20120242

Science Based

This article is based on scientific studies, written by Winston Peki and fact-checked by experts.

Inside this article, you can find references to peer-reviewed scientific studies. The numbers in the parentheses (1, 2, …) are clickable links to these peer-reviewed scientific studies. In some cases, the link will give you direct access to the study, while in other cases if you want to read the full study, you either have to pay the publisher a fee or find a free version of the study elsewhere.

Herbonaut is a review and discussion platform that highly values honesty, integrity, and objectivity. We always strive to highlight the benefits, as well as the risks of a specific product or service.

Any topic can be approached from various angles, at Herbonaut we strive to highlight all these angles and will often examine and compare research with contradicting results.