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Science Based 26

By

Winston Peki

CBN VS CBD: Similarities, Differences, and Use Cases

CBN vs CBD New

Today, we’re going to discuss CBN and CBD, and their:

  • similarities,
  • differences, and;
  • use cases.

We reviewed 21 studies and found that CBD and CBN are both similar and different in many ways.

By reading this article, you will be able to get a better understanding of how CBN and CBD can affect the body.

Summary of Main Points

  • CBN and CBD interact with some of the same receptors, including TRPV1 and GPR55;
  • CBN interacts more strongly with the cannabinoid receptors (CB1 and CB2) than CBD;
  • High doses of CBN may lead to psychoactive effects;
  • Both CBD and CBN may be helpful for pain relief;
  • Both CBD and CBN may improve sleep in specific circumstances;
  • CBN appears to be a stronger sedative than CBD. This may result in side effects like fatigue and grogginess with much lower doses than CBD;
  • More research supports the use of CBD for use cases like pain relief, anxiety relief, and improvement of sleep;
  • CBN research is still in its infancy.

Table of contents:

What Is CBN?

What Is CBD?

What Are the Similarities Between CBN and CBD?

What Are the Differences Between CBN and CBD?

CBN vs CBD for Pain

CBN vs CBD for Anxiety

CBN vs CBD for Sleep

Types of CBN Products

Conclusion

What Is CBN?

CBN, or cannabinol, is a cannabinoid found in the cannabis plant.

Although CBN and CBD are both cannabinoids, CBN is less well-researched.

It’s an oxidation by-product of THC. It forms when THC inside the cannabis plant breaks down from:

  •  drying,
  •  heating, or,
  •  maturation.

You may wonder if CBN will get you high.

Similar to THC, CBN binds to and acts on the CB1 receptor. This means that CBN can be mildly psychoactive at extremely high doses.

While there is limited research on the compound, some studies have shown that CBN:

  • May have nerve-protecting effects, specifically for neurological disorders such as ALS (1).
  • May provide pain relief related to chronic muscle disorders (2).
  • May potentially help with sleep when combined with THC, although research is limited (3, 4).

What Is CBD?

CBD, or cannabidiol, is another cannabinoid found in cannabis. It’s one of the most well-researched cannabinoids.

It has numerous benefits, including:

  • anti-inflammatory effects (5)
  • pain-reducing effects (6)
  • anxiety-reducing effects (7, 8)
  • improvement of sleep, potentially due to its anxiety-relieving benefits (9)

As science continues to back many of the health benefits associated with CBD, the industry continues to bloom. 

The most widely used CBD products currently are oils and tinctures.

What Are the Similarities Between CBN and CBD?

Since CBN and CBD are both cannabinoids, it’s valid to assume they share similarities.

Effects of CBN and CBD

CBN and CBD interact with some of the same receptors in the body. These include:

  • TRPV1, which influences pain response (10)
  • GPR55, which may influence anxiety and inflammation (11, 12)
  • Cannabinoid receptor 1 and 2, or CB1 and CB2 (13)

By interacting with the same receptors, CBN and CBD can induce similar benefits and side effects within the body. This will be discussed below.

Benefits of CBN and CBD

Pain Relief: A study conducted on rats in 2019 suggested that both CBN and CBD may alleviate feelings of pain (2).

This is attributed to the cannabinoids’ interactions with the TRPV1 receptor.

Sleep: Both CBD and CBN may be associated with enhanced sleep in specific circumstances.

However, findings are contradictory. This requires further analysis, which we will unpack at a later stage.

Anti-inflammation: Research is highlighting the effect that cannabinoids have on fighting inflammation (14).

CBN and CBD both seem to induce anti-inflammatory responses in the body.

This may be useful for conditions such as arthritis, although further research is needed.

Side Effects of CBN and CBD

Both CBN and CBD can have sedative-like effects on the body.

This means that they both may cause drowsiness and fatigue at high doses. 

Some users claim that CBN has more potent sedative effects than CBD. This also has been our experience reviewing various CBN products. This can be good if you’re looking to sleep. But the other side is that CBN can produce grogginess and fatigue in much lower doses than CBD.

What Are the Differences Between CBN and CBD?

Although CBD and CBN are both cannabinoids, they differ in many ways.

Effects of CBN vs. CBD

As mentioned previously, both compounds interact with similar receptors.

However, it must be noted that CBN actually binds to the CB1 and CB2 receptors, whereas CBD only weakly interacts with them. But CBD interacts more strongly with the endocannabinoid system, including the CB1 and CB2 receptors, in an indirect way.

Direct activation of the CB1 receptor can cause psychoactive effects. This is exactly what THC does.

This is why CBN may potentially exhibit psychoactive properties in large doses, whereas CBD would not.

Benefits of CBN vs. CBD

A systematic review has highlighted the benefits that CBD has towards addictions (15).

According to the review, both animal and human studies suggest that CBD can be used as an intervention for addictive behaviors.

A number of studies that CBD helps regulate addictive behaviors towards:

  • Cocaine,
  • Opioid, and;
  • Psychostimulant addiction.

On the other hand, there are currently no studies on the therapeutic effects of CBN towards addiction.

Other than that, a lot of the claimed benefits of CBD and CBN overlap.

But there’s more scientific and anecdotal evidence supporting CBD’s benefits for purposes like:

  • anxiety relief,
  • reducing inflammation, and,
  • relieving pain.

This doesn’t mean CBD is more beneficial for these purposes. We won’t know which cannabinoid is more effective for what until more research goes into both cannabinoids.

Side Effects of CBN vs. CBD

While CBD is regarded as a safe compound, it may cause issues at high doses (16). These may include:

  • Diarrhea,
  • Drug interactions,
  • Alterations in appetite and weight, and;
  • Changes in blood pressure.

On the other hand, CBN’s side effects are still unclear. This does not mean that it doesn’t have any, but that the research is still in its early stages. 

User reports and our own experience show that CBN can cause grogginess and tiredness at lower doses than CBD.

Some users report these side effects with doses starting from 30mg CBN. While a dose of 30mg CBD will rarely cause side effects for anyone.

CBN vs CBD for Pain

As previously mentioned, both CBD and CBN have potential pain relief benefits.

It is time to take a deeper look.

How can CBD reduce feelings of pain?

According to a recent review article, CBD has multiple mechanisms of action when it comes to relieving pain (17).

  1. While it has low affinity for cannabinoid receptors, it’s an inverse agonist of the CB2 receptor (18). There’s evidence that CB2 receptor inverse agonism can inhibit immune cell migration and contribute anti-inflammatory effects (19).
  2. CBD inhibits the breakdown of an endocannabinoid known as Anandamide (AEA). Higher levels of AEA may contribute to pain relief (20).
  3. It inhibits the TRPV1 receptor. Decreased TRPV1 levels are also associated with reduced pain (21).

Similar to CBD, CBN has potential as a pain reliever. This benefit has also been attributed to the inhibition of the TRPV1 receptor (22).

Although less potent than CBD, one animal study found that CBN can inhibit anandamide breakdown as well (23).

Although weaker than THC, CBN also acts as an agonist (activator) of the CB1 receptor. Activation of the CB1 receptor has been associated with reduced pain.

Looking at how CBN works, it’s likely that it has pain-relieving properties as well.

Since research on CBN’s effects is still limited, a combination of both CBD and CBN are recommended for pain relief.

CBN vs CBD for Anxiety

A review article has highlighted the healing benefits of CBD for patients struggling with anxiety and depression (24). A recent study has reinforced these claims by highlighting CBD’s effect on short term stress responses (25).

CBD activates a serotonin sub-type receptor, the 5-HT1A receptor. Studies show that CBD that this activation may be responsible for its anti-anxiety effects (26).

5-HT1A receptor activation, is associated with a reduction in stress levels.

In contrast, the effects of CBN on stress and anxiety are not yet known.

Does this mean that CBN has no influence on stress and anxiety?

No. Various user reports on public fora like Reddit show that CBN could work as an anxiety-reliever.

But there’s no scientific study that looked at the effects of CBN on anxiety.

CBN’s user reports stating its anxiety-reducing effects, highlight the need for further research.

CBN vs CBD for Sleep

Studies have highlighted the potential for CBD to be used as a sleep aid (27).

But how exactly does CBD help with sleep problems?

The exact mechanism of action is still not known. However, as mentioned previously, CBD may help regulate sleep due to its anxiety- and stress-relieving effects.

And what about CBN?

CBN’s potential effect on sleep is what garnered attention from the public. Today, there are countless companies selling CBN oils online.

While there is limited research highlighting CBN’s potential to act as a sedative, there are countless anecdotal references online from users who consume CBN oil for improving sleep.

On the other hand, a recent systematic review stressed the lack of scientific backing for the claimed benefits of CBN for sleep (4).

Despite this, users are still standing by the benefits of CBN oil for sleep. This underlines the need for further research to put an end to the debate.

Types of CBN Products

Since new studies on the benefits of CBN are surely underway, you might be interested in learning about the different types of CBN products available.

Similar to CBD products, CBN can be found as:

  • Oils and tinctures,
  • Capsules,
  • Vape products.

Once more research is conducted, you might begin to find CBN in other forms.

Conclusion

From what we know so far, CBD and CBN have many similarities and differences.

Both CBD and CBN could be useful for relieving anxiety and pain, improving sleep, and reducing inflammation.

That said, the effects of CBN aren’t well-researched currently. CBD has more scientific evidence to support its use for these purposes.

And although they interact with some of the same receptors, how they interact can differ on a case-by-case basis.

CBN also may have more potent sedative effects than CBD. While this can be a benefit, it also means that CBN can produce side effects like fatigue and grogginess in lower doses than CBD.

With the new spotlight on CBN, more literature on the effects and benefits will be made available soon.

With that being said, CBN is proving to be a safe cannabinoid, with potential benefits to be discovered.

What’s Next…

Go  to our CBD Hub to learn more about CBD-related topics.

Scientific References:

  1. Weydt, P., Hong, S., Witting, A., Möller, T., Stella, N., & Kliot, M. (2005). Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival. Amyotrophic Lateral Sclerosis, 6(3), 182–184. https://doi.org/10.1080/14660820510030149
  2. Wong, H., & Cairns, B. E. (2019). Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain. Archives of Oral Biology, 104, 33–39. https://doi.org/10.1016/j.archoralbio.2019.05.028
  3. Karniol, I. G., Shirakawa, I., Takahashi, R. N., Knobel, E., & Musty, R. E. (1975). Effects of &Delta;<sup>9</sup>-Tetrahydrocannabinol and Cannabinol in Man. Pharmacology, 13(6), 502–512. https://doi.org/10.1159/000136944
  4. Corroon, J. (2021). Cannabinol and Sleep: Separating Fact from Fiction. Cannabis and Cannabinoid Research. https://doi.org/10.1089/can.2021.0006
  5. Burstein, S. (2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry, 23(7), 1377–1385. https://doi.org/10.1016/j.bmc.2015.01.059
  6. Capano, A., Weaver, R., & Burkman, E. (2019). Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgraduate Medicine, 132(1), 56–61. https://doi.org/10.1080/00325481.2019.1685298
  7. Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Filho, A. S., Freitas-Ferrari, M. C., McGuire, P. K., Zuardi, A. W., Busatto, G. F., & Hallak, J. E. C. (2010). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology, 25(1), 121–130. https://doi.org/10.1177/0269881110379283
  8. Shannon, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal, 23. https://doi.org/10.7812/tpp/18-041
  9. Kesner, A. J., & Lovinger, D. M. (2020). Cannabinoids, Endocannabinoids and Sleep. Frontiers in Molecular Neuroscience, 13. https://doi.org/10.3389/fnmol.2020.00125
  10. Starkus, J., Jansen, C., Shimoda, L. M. N., Stokes, A. J., Small-Howard, A. L., & Turner, H. (2019). Diverse TRPV1 responses to cannabinoids. Channels, 13(1), 172–191. https://doi.org/10.1080/19336950.2019.1619436
  11. Shi, Q. X., Yang, L. K., Shi, W. L., Wang, L., Zhou, S. M., Guan, S. Y., Zhao, M. G., & Yang, Q. (2017). The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress. Molecular Brain, 10(1). https://doi.org/10.1186/s13041-017-0318-7
  12. Saliba, S. W., Jauch, H., Gargouri, B., Keil, A., Hurrle, T., Volz, N., Mohr, F., Van der Stelt, M., Bräse, S., & Fiebich, B. L. (2018). Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. Journal of Neuroinflammation, 15(1). https://doi.org/10.1186/s12974-018-1362-7
  13. Pertwee, R. G. (2008). The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. British Journal of Pharmacology, 153(2), 199–215. https://doi.org/10.1038/sj.bjp.0707442
  14. Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future Medicinal Chemistry, 1(7), 1333–1349. https://doi.org/10.4155/fmc.09.93
  15. Prud’homme, M., Cata, R., & Jutras-Aswad, D. (2015). Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence. Substance Abuse: Research and Treatment, 9, SART.S25081. https://doi.org/10.4137/sart.s25081
  16. Huestis, M. A., Solimini, R., Pichini, S., Pacifici, R., Carlier, J., & Busardò, F. P. (2019). Cannabidiol Adverse Effects and Toxicity. Current Neuropharmacology, 17(10), 974–989. https://doi.org/10.2174/1570159×17666190603171901
  17. Thomas, A., Baillie, G. L., Phillips, A. M., Razdan, R. K., Ross, R. A., & Pertwee, R. G. (2007). Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British journal of pharmacology, 150(5), 613–623. https://doi.org/10.1038/sj.bjp.0707133
  18. Lunn, C. A., Fine, J. S., Rojas-Triana, A., Jackson, J. V., Fan, X., Kung, T. T., Gonsiorek, W., Schwarz, M. A., Lavey, B., Kozlowski, J. A., Narula, S. K., Lundell, D. J., Hipkin, R. W., & Bober, L. A. (2005). A Novel Cannabinoid Peripheral Cannabinoid Receptor-Selective Inverse Agonist Blocks Leukocyte Recruitment in Vivo. Journal of Pharmacology and Experimental Therapeutics, 316(2), 780–788. https://doi.org/10.1124/jpet.105.093500
  19. Clapper, J. R., Moreno-Sanz, G., Russo, R., Guijarro, A., Vacondio, F., Duranti, A., Tontini, A., Sanchini, S., Sciolino, N. R., Spradley, J. M., Hohmann, A. G., Calignano, A., Mor, M., Tarzia, G., & Piomelli, D. (2010). Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nature Neuroscience, 13(10), 1265–1270. https://doi.org/10.1038/nn.2632
  20. Costa, B., Giagnoni, G., Franke, C., Trovato, A. E., & Colleoni, M. (2004). Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. British Journal of Pharmacology, 143(2), 247–250. https://doi.org/10.1038/sj.bjp.0705920
  21. De Petrocellis, L., Ligresti, A., Moriello, A. S., Allarà, M., Bisogno, T., Petrosino, S., Stott, C. G., & Di Marzo, V. (2011). Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. British Journal of Pharmacology, 163(7), 1479–1494. https://doi.org/10.1111/j.1476-5381.2010.01166.x
  22. WATANABE, K., KAYANO, Y., MATSUNAGA, T., YAMAMOTO, I., & YOSHIMURA, H. (1996). Inhibition of Anandamide Amidase Activity in Mouse Brain Microsomes by Cannabinoids. Biological and Pharmaceutical Bulletin, 19(8), 1109–1111. https://doi.org/10.1248/bpb.19.1109
  23. Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018). Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.02009
  24. Spinella, T. C., Stewart, S. H., Naugler, J., Yakovenko, I., & Barrett, S. P. (2021). Evaluating cannabidiol (CBD) expectancy effects on acute stress and anxiety in healthy adults: a randomized crossover study. Psychopharmacology, 238(7), 1965–1977. https://doi.org/10.1007/s00213-021-05823-w
  25. Wright, M., Di Ciano, P., & Brands, B. (2020). Use of Cannabidiol for the Treatment of Anxiety: A Short Synthesis of Pre-Clinical and Clinical Evidence. Cannabis and Cannabinoid Research, 5(3), 191–196. https://doi.org/10.1089/can.2019.0052
  26. Moltke, J., & Hindocha, C. (2021). Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems. Journal of Cannabis Research, 3(1). https://doi.org/10.1186/s42238-021-00061-5

Post last updated on: April 26, 2022

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Winston Peki

Reviewing vaporizers, growing supplies, CBD products and scientific articles about cannabis, cannabinoids, and vaping since 2012. Read more about Winston here. LinkedIn

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© Copyright www.herbonaut.com · All Rights Reserved. The content on this website is for informational purposes only and is not intended as medical advice. Medical advice should always be obtained from a qualified medical professional for any health conditions or symptoms associated with them. Every possible effort has been made in preparing and researching this material. We make no warranties with respect to the accuracy, applicability of its contents or any omissions.

Science Based

This article is based on scientific studies, written by Winston Peki and fact-checked by experts.

Inside this article, you can find references to peer-reviewed scientific studies. The numbers in the parentheses (1, 2, …) are clickable links to these peer-reviewed scientific studies. In some cases, the link will give you direct access to the study, while in other cases if you want to read the full study, you either have to pay the publisher a fee or find a free version of the study elsewhere.

Herbonaut is a review and discussion platform that highly values honesty, integrity, and objectivity. We always strive to highlight the benefits, as well as the risks of a specific product or service.

Any topic can be approached from various angles, at Herbonaut we strive to highlight all these angles and will often examine and compare research with contradicting results.

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Scientific References

Weydt, P., Hong, S., Witting, A., Möller, T., Stella, N., & Kliot, M. (2005). Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival. Amyotrophic Lateral Sclerosis, 6(3), 182–184. https://doi.org/10.1080/14660820510030149

Wong, H., & Cairns, B. E. (2019). Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain. Archives of Oral Biology, 104, 33–39. https://doi.org/10.1016/j.archoralbio.2019.05.028

Karniol, I. G., Shirakawa, I., Takahashi, R. N., Knobel, E., & Musty, R. E. (1975). Effects of &Delta;<sup>9</sup>-Tetrahydrocannabinol and Cannabinol in Man. Pharmacology, 13(6), 502–512. https://doi.org/10.1159/000136944

Corroon, J. (2021). Cannabinol and Sleep: Separating Fact from Fiction. Cannabis and Cannabinoid Research. https://doi.org/10.1089/can.2021.0006

Burstein, S. (2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry, 23(7), 1377–1385. https://doi.org/10.1016/j.bmc.2015.01.059

Capano, A., Weaver, R., & Burkman, E. (2019). Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgraduate Medicine, 132(1), 56–61. https://doi.org/10.1080/00325481.2019.1685298

Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Filho, A. S., Freitas-Ferrari, M. C., McGuire, P. K., Zuardi, A. W., Busatto, G. F., & Hallak, J. E. C. (2010). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology, 25(1), 121–130. https://doi.org/10.1177/0269881110379283

Shannon, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. The Permanente Journal, 23. https://doi.org/10.7812/tpp/18-041

Kesner, A. J., & Lovinger, D. M. (2020). Cannabinoids, Endocannabinoids and Sleep. Frontiers in Molecular Neuroscience, 13. https://doi.org/10.3389/fnmol.2020.00125

Starkus, J., Jansen, C., Shimoda, L. M. N., Stokes, A. J., Small-Howard, A. L., & Turner, H. (2019). Diverse TRPV1 responses to cannabinoids. Channels, 13(1), 172–191. https://doi.org/10.1080/19336950.2019.1619436

Shi, Q. X., Yang, L. K., Shi, W. L., Wang, L., Zhou, S. M., Guan, S. Y., Zhao, M. G., & Yang, Q. (2017). The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress. Molecular Brain, 10(1). https://doi.org/10.1186/s13041-017-0318-7

Saliba, S. W., Jauch, H., Gargouri, B., Keil, A., Hurrle, T., Volz, N., Mohr, F., Van der Stelt, M., Bräse, S., & Fiebich, B. L. (2018). Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. Journal of Neuroinflammation, 15(1). https://doi.org/10.1186/s12974-018-1362-7

Pertwee, R. G. (2008). The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. British Journal of Pharmacology, 153(2), 199–215. https://doi.org/10.1038/sj.bjp.0707442

Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009). Cannabinoids as novel anti-inflammatory drugs. Future Medicinal Chemistry, 1(7), 1333–1349. https://doi.org/10.4155/fmc.09.93

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